Endocrine Abstracts

Aim: To evaluate sleep architecture of patients with Cushing’s disease (CD) and to explore whether agouti-related peptide (AgRP) leptin, and interleukin-6 (IL-6) play a permissive role in sleep alterations.Methods: We performed polysomnography on 26 patients with active CD and age 26 age- and sex-matched control subjects. Blood samples were obtained from all participants for the analyses of AgRP, leptin, and IL-6. The laboratory and sleep-related pa...

Aim: To investigate the volumetric changes in cortical and subcortical deep gray matter (GM) structures and cognitive alterations in patients with mild autonomous cortisol secretion (MACS). We also sought to assess whether the anticipated changes in brain volume and cognitive functions of the patients with MACS differ from the changes in patients with overt Cushing’s Syndrome (CS). Methods: In this cross-sectional study, volumes of the cortex, hippo...

Objective: To test the utility of the artificial learning algorithms using magnetic resonance (MR) images of the pituitary gland in predicting the prognosis of prolactinoma.Methods: This single-center, retrospective study was conducted in the Pituitary Center of a tertiary care university hospital. A total of 224 images derived from 38 patients with treatment-refractory prolactinoma, 23 patients with prolactinoma remission and 51 healthy individuals were...

Introduction: Acromegaloidism is characterized by features of acromegaly without excessive GH secretion.Case report: A 24-year-old male presented with acral enlargement and bilateral non-inflammatory wrist and ankle pain. He had coarse facial features, prominent clubbing, enlarged hands and feet. BMI was 21.3 kg/m2. He did not have a relevant personal and family history. He was not on any medication. Due to his acromegaloid appearance he was r...

Objective: We aimed to examine sexual dysfunction frequency and relationship between sexual dysfunction and androgen level in polycystic ovary syndrome.Patients and methods: Twenty-five PCOS patients were recruited from the outpatient clinics of the Division of Endocrinology in the Department of Internal Medicine and outpatient clinics of the Department Obstetrics and Gynecology at the Cerrahpasa Medical Faculty. Twenty-five healthy volunteer age and sex...

Purpose: To determine the prevalence of nodular thyroid disease, autoimmune thyroid disease, goiter and primary thyroid dysfunction in patients with active Cushing’s disease.Patients and methods: Nineteen patients with active Cushing’s disease (17 female, 2 male, mean age 43.16±3.55 years) and forty, age and gender matched healthy volunteers who served as the control group (34 female, 6 male, mean age 47.28±2.31 years) were included i...

Aim: To determine the prevalence of impulse control disorder (ICD) in patients with Cushing’s disease (CD) treated with cabergoline (CBG) compared to CBG-naive patients with CD.Methods: We performed a cross-sectional study in patients with CD followed at 5 referral centers based in Istanbul. Eligible patients with CD were those with current CBG treatment for ≥ 3 months. Eligible controls were CBG-naive patients with CD that were matched for ag...

Purpose: Patients with acromegaly may have changes in balance due to visual disturbances, musculoskeletal abnormalities and changes in body composition. We aim to compare static and dynamic balances in patients with acromegaly and healthy controls and to evaluate effects of exercise on balance in patients with acromegaly.Methods: Twenty-two patients with acromegaly followed at the Endocrinology Outpatient Clinic of Istanbul University, Cerrahpasa Medical...

Purpose: The authors review the clinical outcomes of patients with hypophysitis.Methods: Medical records of hypophysitis patients who were followed between 2007 and 2018 at Cerrahpasa Medical Faculty were evaluated retrospectively. Clinical, endocrinological, pathological and radiological findings and therapies were assessed.Results: Twenty patients (F/M:12/8) were identified with a mean age at diagnosis of 39.14±17.78 years. ...

Background/AimsGender affirming hormone therapy (GAHT) has been reported to have positive psychosocial effects on transgender people. In present study, we aimed to investigate longitudinally the short-term and long-term impacts on social adaptation, body image, features of alexithymia and aggression changes in transgender men after GAHT administration.MethodsThe single center, longitudinally follow-up study i...